Second Neoplasms in Diffuse Large B-Cell Lymphoma: The Role of Race

Oncology Research Unit, Oncology Hospital, National Medical Center, Avenida, Mexico

*Corresponding author: Agustin Aviles Oncology Research Unit, Oncology Hospital, National Medical Center, Avenida Cuauhtemoc 330, Colonia Doctores, Ciudad de, Zip 06620, Mexico, Tel: + 52 5556276959. Email: [email protected]

Received: December 13, 2022
Published: January 18, 2023

Citation: Agustin A. (2023). Second Neoplasms in Diffuse Large B-Cell Lymphoma: The Role of Race. Cases. 2(1):09.

Copyright: Agustin A. © (2023).

ABSTRACT

Aim: Patients with diffuse large B-cell lymphoma, (DLBCL) have an increased risk to develop a second neoplasm (SN). Multiple factors have been considered at risk: age, familial history, smoking, use of alkylating agents, or etoposide at increased doses, and especially radiotherapy. Moreover, most of the studies have been performed in USA and Europe countries, with a preponderance of white population. The aim of the study is analyze a large number of patients with DLBCL in a search to define the presence of SN in a Mestizo population. Patients and Methods: Electronic files of patients with pathological confirmed diagnosis of DLBCL, treated in our hospital between August 1988 to December 2020; age> 18 years age treated, with combined chemotherapy that were in complete response for at least 3 years. Probably factors associated were analyzed. Median follow-up were 22.4 (range 3.1 to 31.8) years. Results: A total of 9316 patients were evaluated, only 16 cases (0.16%) developed SN. Neither of previous mentioned risks factors: age, gender, smoking doses of chemotherapeutic drugs, alkylating agents, use of radiotherapy, advance stage, elevated International Prognostic index, history of cancer, not were associated to the development of a SN, only race were different, 98 % of our patients were mestizo race. Until now race has not been considered as a factor to be associated with the development of a SN. Conclusion: The unique differences in large number of cases and longer follow-up, was that the presence of an non-white populations, thus it is appear that in an Mestizo population race could have any protective possibility.

Keywords: Diffuse large B-cell lymphoma, radiotherapy, second neoplasms, race, and Mestizo race.